https://www.terrainlifescience.com/blog/ Two voices on one timeline. Newest first. en Wed, 07 Oct 2026 12:00:00 GMT https://www.terrainlifescience.com/blog/every-panel-starts-from-zero/ https://www.terrainlifescience.com/blog/every-panel-starts-from-zero/ Wed, 07 Oct 2026 12:00:00 GMT Why protein tissue tests don't compound, and what it would take to make them. J. Lee https://www.terrainlifescience.com/blog/spatial-biology-has-a-budget/ https://www.terrainlifescience.com/blog/spatial-biology-has-a-budget/ Tue, 06 Oct 2026 12:00:00 GMT Spatial biology maps which molecules sit where, cell by cell, in intact tissue. One family of methods captures molecules on barcoded bins of a slide and reads them out by bulk sequencing. The other, our subject here, photographs targets in place: single molecules or amplified copies that show up as points of light. J. Lee https://www.terrainlifescience.com/blog/the-cheapest-primer-wins/ https://www.terrainlifescience.com/blog/the-cheapest-primer-wins/ Sun, 04 Oct 2026 12:00:00 GMT A year or so into my postdoc, a box of forty antibodies arrived in the lab. It had cost about $30,000. I had proposed we would barcode every one of them, stain pluripotent stem cells with the whole set at once, and read out which proteins were on in which cell. Within weeks it was clear the plan wouldn't scale. The antibodies were fine. The economics weren't. J. Lee https://www.terrainlifescience.com/blog/reading-a-tissues-history/ https://www.terrainlifescience.com/blog/reading-a-tissues-history/ Fri, 02 Oct 2026 12:00:00 GMT A map of which cells sit where is not a tissue's history. The question is the decisions those cells made, and what we would have to measure to reconstruct them. J. Lee